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 Topical solasodine glycoalkaloids in 2007 study
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dan

606 Posts

Posted - 09/09/2008 :  00:58:13  Show Profile  Reply with Quote
The active ingredient in Curaderm and most probably the eggplant and apple cider vinegar skin cancer remedy was studied as a treatment for basal cell carcinoma as reported in the International Journal of Dermatology Volume 47 Issue 1, Pages 78 - 82 Published Online: 17 Dec 2007

Two topical treatments were compared in the study. The first (the control vehicle) was composed of the following: 15% emulsifying wax, 10% white soft paraffin, 10% salicylic acid (aspirin), 5% urea, and 5% propylene glycol. The other treatment called Zycure was composed of the vehicle plus 0.005% solasodine glycosides.

Results: Efficacy at 8 weeks was 66% (41/62) in the Zycure group, compared to 25% (8/32) in the control vehicle group. Ninety percent (37/41) of the Zycure group completed follow-up at six-month intervals for 1 year, of whom 78% (29/37) had no recurrence. There were no major treatment-related adverse effects, although 10 patients in Zycure group did not complete the treatment protocol for various reasons.

Conclusion: We conclude that the solasodine glycoside cream Zycure is a safe therapy for basal cell carcinoma, with a cure rate of 66% at 8 weeks.

Solasodine glycoalkaloids: a novel topical therapy for basal cell carcinoma. A double-blind, randomized, placebo-controlled, parallel group, multicenter study at http://www3.interscience.wiley.com/cgi-bin/fulltext/119389345/PDFSTART

see also http://www.townsendletter.com/AugSept2008/gabyeditorial0808.htm

dan

606 Posts

Posted - 09/10/2008 :  23:27:02  Show Profile  Reply with Quote
There are several takeaways from this topical solasodine glycoalkaloids for skin cancer study.

The active ingredient in Curaderm and the eggplant and apple cider vinegar remedy is safe and quite often completely effective. However, enough people have commented that Curaderm (and for that matter the eggplant ACV remedy) did not work for them to doubt the claim that it was 100% effective against all skin cancers, and now we know better. Only about 50% had complete healing of their skin cancer after one year (29+/62). Plan on using it for at least eight weeks. Probably 12 weeks would have better results. If you are considering Curaderm this means about three $129 bottles according to the Townsend Letter link above. Eggplant ACV is much cheaper but very uncontrolled in terms of quality. If topical solasodine glycoalkaloids work for you, then great! If not, there are lots of other things to try.

Another interesting thing was the "control vehicle" was not exactly a placebo. Evidently aspirin and/or urea have some punch in them against skin cancer, and propylene glycol seems to be at least a safe if not helpful cosmetic ingredient for skin cancer when combining this study result with the recent moisturizer skin cancer study result. Most deodorants seem to use propylene glycol (AKA antifreeze) so maybe that is one less thing to worry about.
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marsha

USA
122 Posts

Posted - 09/11/2008 :  00:55:32  Show Profile  Reply with Quote
Dan are you saying that curaderm has antifreeze in it?
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dan

606 Posts

Posted - 09/13/2008 :  02:00:40  Show Profile  Reply with Quote
As far as I know, Curaderm-BEC5 is composed of solasodine glycosides (BEC), salicylic acid (aspirin), and urea. Curaderm is similar to Zycure used in the study but does not seem to contain propylene glycol, listed as a "moderate" hazard at http://www.cosmeticdatabase.com/ingredient.php?ingred06=705315

FYI, urea is also listed as a "moderate" hazard http://www.cosmeticdatabase.com/ingredient.php?ingred06=706791

Salicylic acid (aspirin) is listed as a "high" hazard http://www.cosmeticdatabase.com/ingredient.php?ingred06=705746

I don't think these hazard ratings would stop me from using Zycure or Curaderm on a skin cancer.
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KMWS

USA
18 Posts

Posted - 01/06/2017 :  22:20:27  Show Profile  Reply with Quote
What does "BEC" stand for?
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gloe

124 Posts

Posted - 01/23/2017 :  12:10:52  Show Profile  Reply with Quote
quote:
Originally posted by KMWS

What does "BEC" stand for?



I think BEC are the initials of the person who developed the formula.
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Eddie_T

USA
13 Posts

Posted - 03/01/2017 :  15:29:13  Show Profile  Reply with Quote
Saliciylic acid is not asprin, try acetylsalicylic acid. Saliciylic acid is used in wart and corn remover compound.
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anivoc

640 Posts

Posted - 03/01/2017 :  18:02:22  Show Profile  Reply with Quote
Same active ingredient....just chemically modified to make it more palatable and faster acting...

Salicylic acid originally came in the form of white willow tree bark extract. People have used this park for centuries as an analgesic and antipyretic. (fever, pain and inflammation) This had a very bitter taste and caused gastric mucosa irritation. Around 1897 it was discovered that a simple chemical modification change to acetylsalicylic acid made it much more palatable. It became commercially available as the first blockbuster drug and so the pharmaceutical age began.

Acetylation helps a given drug reach the brain more quickly, making the drug's effects more intense and increasing the effectiveness of a given dose. The acetyl group in acetylsalicylic acid (aspirin) enhances its effectiveness relative to the natural anti-inflammatant salicylic acid.
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Eddie_T

USA
13 Posts

Posted - 03/02/2017 :  14:21:24  Show Profile  Reply with Quote
I have been trying the eggplant vinegar approach but suspect that its concentration is too low to be very effective. A means of extraction
(maybe alcohol) that could be evaporated into a powder that could be added to a petrolatum or other base might prove more effective.

While debating whether to pay the price for Curaderm I ran across Flonida flououracil cream at $12.39 per 10gm tube (Ebay) shipped from India.

Edited by - Eddie_T on 03/02/2017 15:05:31
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anivoc

640 Posts

Posted - 03/02/2017 :  22:25:25  Show Profile  Reply with Quote
Hi Eddie

I encourage you to completely read through the threads on both the eggplant / vinegar combo and Curaderm before investing to much time, energy, pain and money into those two particular approaches. Personally having tried both my only regret is trying them. IMO ( and that's just my opinion) the eggplant / vinegar thing is a total waste of time on anything other than a very superficial AK ...Curaderm...maybe on a small BCC but Bloodroot paste albeit very painful, is hands down far superior...Facebook has a couple Bloodroot paste groups you can join where you can see real people sharing their real time experiences daily there. all the best whatever route you choose.
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Eddie_T

USA
13 Posts

Posted - 03/04/2017 :  00:45:49  Show Profile  Reply with Quote
Good advice! I tried Curaderm back when vitamin catalogs carried it for $65 and it was in a small plastic bottle. It failed to cure an AK which I later cured with Efudex. I found the remains of the bottle in a drawer and am trying it on a couple of spots. Is is lighting up the skin but so far that's all. I did order a couple of tubes of Flonida which I will try. At present I am using Curaderm at night and eggplant-vinegar-dmso during the day. Vitamin C-dmso or tumeric-dmso if I go out during the day as it doesn't show as much. I may go to Cansema if I don't get good results with Flonida when it arrives. A friend had good results with Can-X apparently a fore runner of Cansema.
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Disclaimer: The three most common types of skin cancer are basal cell carcinoma, squamous cell carcinoma, and melanoma. While melanoma is the most dangerous type, keep in mind that any cancer and potentially some cancer treatments can cause injury or death. The various views expressed in these public forums should not be considered as medical advice. See your qualified health-care professional for medical attention, advice, diagnosis, and treatments.