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 Sugar feeds cancer, fructose feeds cancer growth
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dan

608 Posts

Posted - 08/05/2010 :  22:09:03  Show Profile  Reply with Quote
You have probably heard the saying "Sugar feeds cancer" A new paper at http://cancerres.aacrjournals.org/content/70/15/6368.abstract looks at the impact of the popular sweetener fructose (fruit sugar) on cancer and finds that fructose fuels cancer cell proliferation.

Fructose Induces Transketolase Flux to Promote Pancreatic Cancer Growth

Carbohydrate metabolism is pivotal for cancer growth, and increased refined carbohydrate consumption adversely affects cancer survival. Traditionally, glucose and fructose have been considered as interchangeable monosaccharide substrates that are similarly metabolized, and little attention has been given to sugars other than glucose. However, fructose intake has increased dramatically in recent decades and cellular uptake of glucose and fructose uses distinct transporters. Here, we report that fructose provides an alternative substrate to induce pancreatic cancer cell proliferation. Importantly, fructose and glucose metabolism are quite different.

These findings show that cancer cells can readily metabolize fructose to increase proliferation. They have major significance for cancer patients given dietary refined fructose consumption, and indicate that efforts to reduce refined fructose intake or inhibit fructose-mediated actions may disrupt cancer growth. Cancer Res; 70(15); 636876.


Originally it was thought that fructose would be somewhat healthier than glucose because of its lower glycemic index, around 20 compared to 100 for glucose. More fructose information can be found at http://en.wikipedia.org/wiki/Fructose and http://lowcarbdiets.about.com/od/nutrition/a/fructosedangers.htm

dan

608 Posts

Posted - 08/29/2010 :  20:46:26  Show Profile  Reply with Quote
I keep running across things that say how bad fructose is for health, yet it is being put in more and more foods. The latest is a youtube video http://www.youtube.com/watch?v=dBnniua6-oM with Dr Robert Lustig from UCSF. He is convincing that fructose is the primary reason people are getting more obese along with all the health complications that go with obesity. His conclusion is that fructose is a poison, much the same that ethanol alcohol is a poison. He says fructose is "alcohol without the buzz." Watching this has convinced me to watch my diet and eliminate fruit juices. Fructose together with fiber (whole fruit) is not nearly as detrimental.
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thanks01

USA
170 Posts

Posted - 08/30/2010 :  17:49:31  Show Profile  Reply with Quote
Dan,
Thanks for the last sentence because, though I try to reduce/avoid the sugars all the time, I find it hard to resist the occasional piece of fruit! In fact, the end of August in the Northeast poses quite a few temptations. I try to keep the peaches and pears, etc. down to "once"!!
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jeffleigh

Australia
3 Posts

Posted - 05/28/2012 :  13:45:04  Show Profile  Reply with Quote
People apparently believe that High Fructose Corn Syrup is particularly bad compared to ordinary sugar, but HFCS ranges from 42% fructose to 55% fructose. Ordinary sugar, (or sucrose) is composed of 50% glucose and 50% fructose, so really, not much difference. Fructose can only be metabolised by the liver which creates a cascade of harmful by-products, whereas glucose is metabolised by every cell in the body. Xylitol is a safe sugar substitute and is particularly healthy for the teeth, although a bit expensive

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Disclaimer: The three most common types of skin cancer are basal cell carcinoma, squamous cell carcinoma, and melanoma. While melanoma is the most dangerous type, keep in mind that any cancer and potentially some cancer treatments can cause injury or death. The various views expressed in these public forums should not be considered as medical advice. See your qualified health-care professional for medical attention, advice, diagnosis, and treatments.