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 Gender differences for skin cancer in mice study
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dan

608 Posts

Posted - 04/02/2007 :  22:47:18  Show Profile  Reply with Quote
A new study (April 1, 2007) in Cancer Research http://cancerres.aacrjournals.org/cgi/rapidpdf/0008-5472.CAN-06-3798v1.pdf on mice showed males are much more likely to incur skin cancers due to biological and not behavioral differences. In other words, don't blame the higher skin cancer incidence rate for male mice on worse "sun safety" compliance.

The study found male mice developed tumors significantly earlier than the female mice. Male mice developed significantly more tumors than female mice and tended to have larger tumors. Moreover, the total tumor burden in males was nearly twice that in females. In addition to having more tumors and larger tumors, males had tumors of a higher histologic grade than females, suggesting accelerated progression of the tumors. Thus, when receiving identical UVB exposure, male mice have enhanced skin tumor susceptibility.
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Disclaimer: The three most common types of skin cancer are basal cell carcinoma, squamous cell carcinoma, and melanoma. While melanoma is the most dangerous type, keep in mind that any cancer and potentially some cancer treatments can cause injury or death. The various views expressed in these public forums should not be considered as medical advice. See your qualified health-care professional for medical attention, advice, diagnosis, and treatments.