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Author  Topic    trish USA 16 Posts Posted - 04/27/2009 :  19:04:51     Now where and how do we get this stuff? http://stuchebrukhov.ucdavis.edu/DNA_Repair/index.html http://www.ncbi.nlm.nih.gov/pubmed/15668165 BACKGROUND: The high and steadily increasing incidence of ultraviolet-B (UV-B)-induced skin cancer is a problem recognized worldwide. UV introduces different types of damage into the DNA, notably cyclobutane pyrimidine dimers (CPDs) and (6-4) photoproducts (6-4PPs). If unrepaired, these photolesions can give rise to cell death, mutation induction, and onset of carcinogenic events, but the relative contribution of CPDs and 6-4PPs to these biological consequences of UV exposure is hardly known. Because placental mammals have undergone an evolutionary loss of photolyases, repair enzymes that directly split CPDs and 6-4PPs into the respective monomers in a light-dependent and lesion-specific manner, they can only repair UV-induced DNA damage by the elaborate nucleotide excision repair pathway. RESULTS: To assess the relative contribution of CPDs and 6-4PPs to the detrimental effects of UV light, we generated transgenic mice that ubiquitously express CPD-photolyase, 6-4PP-photolyase, or both, thereby allowing rapid light-dependent repair of CPDs and/or 6-4PPs in the skin. We show that the vast majority of (semi)acute responses in the UV-exposed skin (i.e., sunburn, apoptosis, hyperplasia, and mutation induction) can be ascribed to CPDs. Moreover, CPD-photolyase mice, in contrast to 6-4PP-photolyase mice, exhibit superior resistance to sunlight-induced tumorigenesis. CONCLUSIONS: Our data unequivocally identify CPDs as the principal cause of nonmelanoma skin cancer and provide genetic evidence that CPD-photolyase enzymes can be employed as effective tools to combat skin cancer. anivoc 668 Posts Posted - 04/30/2009 :  22:00:33     Wow! I wish I could say I understand all of it.. It appears there is a way to reverse a dna message which in turn reverses the bad cells which we call non melanoma skin cancer back into normal healthy cells.. Here's the full abstract http://www.box.net/shared/8xo86dm9sl It is deep heavy reading way beyond my expertise but from a laymans first impression ( I have not read the whole document ) It appears CPD's are the cause of skin cancer and blue light led (Photolyase)can change their structure back to normal cells... Edited by - anivoc on 05/01/2009 07:26:20    Topic

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