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dan
612 Posts |
 Posted - 08/21/2008 : 01:24:28
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Most metastatic melanoma patients fail to respond to available therapy. An inexpensive prescription medicine called Mebendazole, marketed as Ovex, Vermox, Antiox, or Pripsen, may be the answer for melanoma and perhaps many other types of cancer. Mebendazole is currently used to treat parasitic infestations by worms including pinworms, roundworms, tapeworms, hookworms, and whipworms. http://en.wikipedia.org/wiki/Mebendazole
A number of recent studies have found that mebendazole is a powerful inducer of apoptosis (spontaneous cell death) in a wide variety of cancer cells, both in culture dishes and mouse models. Mebendazole also inhibited angiogenesis (growing of new blood vessels). It is also a spindle poison that induces chromosome nondisjunction (failure of chromosome pairs to separate properly during cell division).
The latest study specifically identifies mebendazole as a potent, melanoma-specific cytotoxic agent. http://mcr.aacrjournals.org/cgi/content/abstract/6/8/1308 (Mol Cancer Res 2008;6(8):1308–15)
An article sent out by Grouppe Kurosawa entitled "Worm Pills, an Effective Treatment for Malignant Melanoma and Other Cancers" can be found in their natural medicine blog at http://grouppekurosawa.com/blog/ The exact link to the article did not open correctly in firefox for me, so I'll repeat some of it here:
The average blood concentration of mebendazole after a single clinical dose is 1.67 microM. This value vastly exceeds the concentration of mebendazole needed to kill a host of different cancer cells. The half maximal cytotoxic dose for melanoma was 0.32 microM.
Mebendazole is usually sold as a 100mg chewable tablet. When chewed and allowed to remain in the mouth for a short period, mebendazole can enter the blood through the mucosal membranes of the mouth. Of course, it can also enter the blood via the GI tract. This drug is extremely non-toxic even in doses of 4.5 grams a day. Cimetidine, the generic version of the anti-ulcer drug Tagamet, increases the effectiveness of mebendazole by inhibiting its degradation in the liver.
Microtubule inhibitors such as Taxol are THE target of interest for chemo drugs. In this case, a simple anti-worm drug inhibits microtubule functioning at low non-toxic concentrations without harming normal cells. In a culture dish and in mice, mebendazole induces apoptosis in a diversity of cancer cells at extremely low concentrations.
Unfortunately, this drug will NEVER enter clinical trials as a treatment for cancer. There is no money to be made. Fortunately, physicians can prescribe this drug for the treatment of cancer without a clinical trial, but you will probably have to take the initiative to present your research on mebendazole or use an offshore pharmacy.
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anivoc
668 Posts |
Posted - 08/23/2008 : 11:11:35
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Interesting Dan
As you probably know Hulda Clark points the finger at parasites as one of the three common denominators in all cancer tumors. The other 2 are copper and freon..
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Melanoma cure?
