| T O P I C R E V I E W |
| dan |
Posted - 08/04/2007 : 01:24:23
Exercise plus caffeine led to much lower rates of skin cancer in a new study with mice. The combination enhanced programmed cell death, also known as apoptosis. Apoptosis is a way in which cells with badly damaged DNA commit suicide – UVB-damaged cells in this case.
“If apoptosis takes place in a sun-damaged cell, its progress toward cancer will be aborted,” said Allan Conney, director of Rutgers’ Cullman Laboratory.
Compared to the UVB-exposed control animals, the caffeine drinkers showed an approximately 95 percent increase in UVB-induced apoptosis, the exercisers showed a 120 percent increase, while the mice that were both drinking and exercising showed a nearly 400 percent increase over a group that had no access to an exercise wheel and had no caffeine.
http://ur.rutgers.edu/medrel/science/conney.shtml
Earlier research at Rutgers found that both topical caffeine and topical EGCG, compounds found in green tea, inhibit skin cancer.
http://www.pnas.org/cgi/reprint/99/19/12455 |
| 3 L A T E S T R E P L I E S (Newest First) |
| sebastian348 |
Posted - 04/08/2008 : 02:25:35
I also heard about this study. Too bad that I am not a coffee drinker :-) Well I guess there are many other ways left for me to prevent skin cancer. |
| sujan20 |
Posted - 12/04/2007 : 02:29:56
I heard about Aloe Vera cream that skin cancer can be resolved by applying Aloe Vera cream liberally over the affected part three times daily for atleast three months. |
| dan |
Posted - 08/06/2007 : 23:42:52
Well, here is my guess at why exercise and caffeine inhibit skin cancer. I think the common denominator is ammonia. Exercise causes an increase in plasma NH3 (ammonia) concentration. Caffeine prevents ammonia from breaking down into urea. Combine the two and there is extra ammonia, which I think possibly promotes cancer cell apoptosis or cell death. Perhaps this is one reason why topical skin cancer treatments with added ammonia (eg, combined with orange oil or pancreatin enzymes) seem to work better.
http://jap.physiology.org/cgi/content/full/85/4/1502 http://www.jbc.org/cgi/reprint/160/1/249.pdf |
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